The World Sees The Rise Of A Different Kind Of Opioid Crisis

KAPURTHALA, India (AP) — Reports rolled in with escalating urgency — pills seized by the truckload, pills swallowed by schoolchildren, pills in the pockets of dead terrorists.

These pills, the world has been told, are safer than the OxyContins, the Vicodins, the fentanyls that have wreaked so much devastation. But now they are the root of what the United Nations named “the other opioid crisis” — an epidemic featured in fewer headlines than the American one, as it rages through the planet’s most vulnerable countries.

Mass abuse of the opioid tramadol spans continents, from India to Africa to the Middle East, creating international havoc some experts blame on a loophole in narcotics regulation and a miscalculation of the drug’s danger. The man-made opioid was touted as a way to relieve pain with little risk of abuse. Unlike other opioids, tramadol flowed freely around the world, unburdened by international controls that track most dangerous drugs.

But abuse is now so rampant that some countries are asking international authorities to intervene.

Grunenthal, the German company that originally made the drug, is campaigning for the status quo, arguing that it’s largely illicit counterfeit pills causing problems. International regulations make narcotics difficult to get in countries with disorganized health systems, the company says, and adding tramadol to the list would deprive suffering patients access to any opioid at all.

“This is a huge public health dilemma,” said Dr. Gilles Forte, the secretary of the World Health Organization’s committee that recommends how drugs should be regulated. Tramadol is available in war zones and impoverished nations because it is unregulated. But it is widely abused for the same exact reason. “It’s a really very complicated balance to strike.”

Tramadol has not been as deadly as other opioids, and the crisis isn’t killing with the ferocity of America’s struggle with the drugs. Still, individual governments from the U.S. to Egypt to Ukraine have realized the drug’s dangers are greater than was believed and have worked to rein in the tramadol trade. The north Indian state of Punjab, the center of India’s opioid epidemic, was the latest to crack down. The pills were everywhere, as legitimate medication sold in pharmacies, but also illicit counterfeits hawked by street vendors.

This year, authorities seized hundreds of thousands of tablets, banned most pharmacy sales and shut down pill factories, pushing the price from 35 cents for a 10-pack to $14. The government opened a network of treatment centers, fearing those who had become opioid addicted would resort to heroin out of desperation. Hordes of people rushed in, seeking help in managing excruciating withdrawal.

For some, tramadol had become as essential as food.

“Like if you don’t eat, you start to feel hungry. Similar is the case with not taking it,” said auto shop welder Deepak Arora, a gaunt 30-year-old who took 15 tablets day, so much he had to steal from his family to pay for pills. “You are like a dead person.”

Jeffery Bawa, an officer with the United Nations Office on Drugs and Crime, realized what was happening in 2016, when he traveled to Mali in western Africa, one of the world’s poorest countries, gripped by civil war and terrorism. They asked people for their most pressing concerns. Most did not say hunger or violence. They said tramadol.

One woman said children stumble down the streets, high on the opioid; parents add it to tea to dull the ache of hunger. Nigerian officials said at a United Nations meeting on tramadol trafficking that the number of people there living with addiction is now far higher than the number with AIDS or HIV.

Tramadol is so pervasive in Cameroon scientists a few years ago believed they’d discovered a natural version in tree roots. But it was not natural at all: Farmers bought pills and fed them to their cattle to ward off the effects of debilitating heat. Their waste contaminated the soil, and the chemical seeped into the trees.

Police began finding pills on terrorists, who traffic it to fund their networks and take it to bolster their capacity for violence, Bawa said.

Most of it was coming from India. The country’s sprawling pharmaceutical industry is fueled by cheap generics. Pill factories produce knock-offs and ship them in bulk around the world, in doses far exceeding medical limits.

In 2017, law enforcement reported that $75 million worth of tramadol from India was confiscated en route to the Islamic State terror group. Authorities intercepted 600,000 tablets headed for Boko Haram. Another 3 million were found in a pickup truck in Niger, in boxes disguised with U.N. logos. The agency warned that tramadol was playing “a direct role in the destabilization of the region.”

“We cannot let the situation get any further out of control,” that alert read.

Grunenthal maintains that tramadol has a low risk of abuse; most of the pills causing trouble are knock-offs, not legitimate pharmaceuticals, and American surveys have shown lower levels of abuse than other prescription painkillers. The company submitted a report to the WHO in 2014, saying that the abuse evident in “a limited number of countries,” should be viewed “in the context of the political and social instabilities in the region.”

But some wealthy countries worried about increasing abuse also have acted to contain the drug.

The United Kingdom and United States both regulated it in 2014. Tramadol was uncontrolled in Denmark until 2017, when journalists asked doctors to review studies submitted to regulators to support the claim that it has a low risk for addiction, said Dr. Karsten Juhl Jorgensen, acting director of the Nordic Cochrane Centre and one of the physicians who analyzed the materials. They all agreed that the documents did not prove it’s safer.

“We know that opioids are some of the most addictive drugs on the face of the planet, so the claim that you’ve developed one that’s not addictive, that’s an extraordinary claim, and extraordinary claims require evidence. And it just wasn’t there,” said Jorgensen. “We’ve all been cheated, and people are angry about that.”

Jorgensen compares claims that tramadol is low risk to those made by American companies now facing thousands of lawsuits alleging misleading campaigns touting the safety of opioids unleashed the U.S. addiction epidemic.

Stefano Berterame, a chief at the International Narcotics Control Board, said there is a critical difference: The crisis is not as deadly as the American one, which began with prescription opioids and transitioned to heroin and fentanyl. Tramadol does not as routinely cause the respiratory depression that leads to overdose death.

But it is mostly afflicting poor nations, where overdose statistics are erratic, he said, so the true toll of tramadol is unknown.

The United Nations established the International Narcotics Control Board in 1961 to spare the world the “serious evil” of addiction. It has since tracked most opioids.

Tramadol’s exemption means authorization isn’t required as the drug moves across borders. Its easy availability also leads to confusion about what tramadol even is, experts say. In many countries, it is thought to be a mood enhancer or treatment for depression and post-traumatic stress. Some take it to improve sexual stamina or endure grueling labor.

Grunenthal synthesized tramadol in the 1960s, as the company was embroiled in scandal over its marketing of the sedative thalidomide, which caused extreme birth defects in thousands of babies whose mothers took it. Tramadol was initially believed to have a low risk of abuse because initial trials studied injected tramadol, the most potent route for most opioids. But researchers later found that tramadol releases a far more powerful dose taken orally because of how it is metabolized by the liver.

Tramadol’s worldwide market quickly expanded in the 1990s. In 2000, the WHO, which assesses medications and recommends scheduling, noted reports of dependence. A committee has reviewed the drug numerous times since, recommended it remain under surveillance but declined to add international regulation.

There is no alternative to tramadol, said Forte, the committee’s secretary. It is the only opioid available in some of the world’s most desperate places; relief organizations rely on it in war zones and natural disasters. It is used extensively not because it is a particularly good medication, he said. The most effective opioid is morphine, but morphine is strictly controlled and countries in crisis fear abuse. Tramadol became the default precisely because it’s uncontrolled.

The WHO is analyzing whether any other drug could take its place but have so far found none. Meanwhile, Forte said, the agency is working with battered nations to ferret out counterfeits.

Legitimate tramadol remains a lucrative business: market research estimates the global market amounts to around $1.4 billion, according to Grunenthal. The medication long ago lost its patent protection. It is now manufactured by many companies and sold under some 500 brand names. Grunenthal markets it as Tramal as well as Zaldiar, tramadol combined with paracetamol. In 2018, those products brought in 174 million euros ($191 million), according to the company’s annual report.

“Our purpose at Grunenthal is to develop and deliver medicines and solutions which address the unmet needs of patients with the goal of improving their quality of life,” the company wrote in a statement that said it acknowledges opioids pose a risk of abuse and addiction. “”We do so with the highest ethical standards.”

Grunenthal also sells other opioids and is expanding around the world. The Associated Press this year revealed executives were swept up in an Italian corruption case alleging they illegally paid a doctor to promote the use of opioids.

The company has campaigned to keep tramadol unregulated. It funded surveys that found regulation would impede pain treatment and paid consultants to travel to the WHO to make their case that it’s safer that other opioids.

Spokesman Stepan Kracala said regulation would not necessarily curtail illicit trade and could backfire: Some desperate pain patients turn to the black market if no legal options exist. Egypt’s long struggle with tramadol abuse is an example, he said. The country enacted strict regulation in 2012 and a later survey found some suffering from cancer using counterfeit tramadol for relief.

Kracala also pointed to regulatory decisions as proof of tramadol’s comparable safety: The U.S. in 2014 added tramadol to its list of controlled substances but included it in a lesser category than opioids like oxycodone or morphine, signaling it is less risky.

There are growing calls to change that.

The Mayo Clinic hospital in Minnesota worked to reduce opioids prescribed post-surgery as the American epidemic escalated, said surgeon Cornelius Thiels. Doctors there started shifting patients to tramadol because it was billed as safer. But Thiels and his colleagues analyzed prescription data and were surprised to find patients prescribed tramadol were just as likely to move on to long-term use.

They published their findings this year to alert authorities, he said: “There is no safe opioid. Tramadol is not a safe alternative. It’s a mistake that we didn’t figure it out sooner. It’s unfortunate that it took us this long. There’s a lot more that we need to learn about it, but I think we know enough that we also can’t wait around to act on this.”

Indian regulators knew the massive quantities manufactured in the country were spilling over domestically and countless Indians were addicted. But S.K. Jha, responsible for the northern region of India’s Narcotics Control Bureau, said he was shocked to learn in 2018 that tramadol from India was ravaging African nations. They realized then they needed to act, he said.

India regulated tramadol in April 2018. Regulators say exports overseas and abuse at home came down. But they acknowledge that the vastness of the pharmaceutical industry and the ingenuity of traffickers makes curtailing abuse and illegal exports all but impossible. Tramadol is still easy to find.

Jyoti Rani stood on her front steps and pointed to house after house where she said tramadol is still sold in her neighborhood of narrow roads and open drains, where school-aged boys sit hunched over the street in the middle of a weekday.

Rani’s addiction began with heroin. When her 14-year-old son died, she fell into depression.

“I wanted to kill myself, but I ended up becoming an addict,” she cried. A doctor prescribed tramadol to help kick the habit — instead, she formed a new one. She locked herself in her room, not eating or taking care of her two children. Rani used tramadol until she ran out of money and entered treatment. Now her family tells her she’s her old self again.

The crackdown on tramadol coincided with the opening of dozens of addiction clinics that administer medicine and counseling to more than 30,000 each day.

“We are trying our level best,” Jha said, “but it’s a challenge for all of us.”

Countries’ efforts to control tramadol on their own often fail, particularly in places where addiction has taken hold, according to the Center for Strategic and International Studies.

India has twice the global average of illicit opiate consumption. Researchers estimate 4 million Indians use heroin or other opioids, and a quarter of them live in the Punjab, India’s agricultural heartland bordering Pakistan, where some of the most vulnerable are driven to drugs out of desperation.

Amandeep Kaur was pregnant when her husband died of a heart attack. She turned to the sex trade to make ends meet. She wanted not to feel, and a fellow sex worker suggested tramadol. She had no idea she’d get addicted, but eventually needed three pills to get through the day.

“If I didn’t have it I felt lifeless, my body ached as if I was going to die,” she said, and joined the line stretching from the addiction clinic’s doors.


By Emily Schmall and Claire Galofaro. Associated Press journalist Rishi Lekhi contributed to this report. This story was produced with support from the Pulitzer Center on Crisis Reporting.

The post The World Sees The Rise Of A Different Kind Of Opioid Crisis appeared first on High Times.

Project Born’s “Crap Or Natural” Now Available Digitally!

Our homies from Project Born have dug deep into their back catalog to make one of their old classics available on CD and digitally for the first time ever!

The album Crap Or Natural which was released back in 1996 on Cassette Only can now be streamed or downloaded!

First, let’s go over the tracklist:

  1. Strugglin’
  2. Getting Fried
  3. All Over The World
  4. Hand On My Glock
  5. Can’t Flex (ft. T-Rock)
  6. World Is A Ghetto (ft. Rashameer McFarland)
  7. Come Up No Downfall
  8. Project Born Fa Life
  9. Cross Da Family (ft. The Project Mob)

Get the album digitally here:

Click to enlarge!



from Faygoluvers

The Bonecast Season 1, Episode 15: Big Trox

The new entertainment video podcast hosted by Bonez Dubb

Season 1 Episode 15 http://TheBonecast.com

Become a sponsor, donate, buy merch and more at http://www.thebonecast.com



from Faygoluvers

Demintid – “Don’t Wanna C Me” (ft. Boondox & Bukshot) [Official Lyric Video]

Brand New Demintid Feat: (Boondox & Bukshot)

editing by : Alex Bleeker

Title: Don’t Wanna C Me !



from Faygoluvers

When An Opera Is Just As Trippy As Any Psychedelic

If you’re a regular reader of High Times, you know that we don’t usually cover operas. We do, however, have 45 years’ experience covering psychedelics and the counterculture at large, so when we were presented with the opportunity to view a breakthrough staging of Wolfgang Amadeus Mozart’s legendary opera, The Magic Flute, we took it — along with some edibles, for good measure.

LA Opera’s hallucinatory staging of Mozart’s beloved opera is a trip unto itself, reminiscent of early silent French films à la George Méliès or the Lumière brothers, only with sound — lots of it. Hand-drawn animations are projected onto a massive two-story white wall, subsuming static scenery with stunning visuals that bring an entirely new dimension to the opera. Not only does the multimedia masterpiece include a quirky, enchanted landscape brought to life by professional vocalists, it’s poised to redefine the way theater will be presented in the future.

Theo Hoffman as Papageno and Zuzana Marková as Pamina in LA Opera’s 2019 production of “The Magic Flute”/ Cory Weaver

Equal parts vaudeville, cabaret, silent film, and opera, this version of The Magic Flute takes the form of a feature film, only the so-called “film” is a compilation of a thousand separate video files that are projected with an 18k lumen projector 120 feet away from the stage. It’s an entirely new kind of presentation that first debuted in 2012 at Komische Oper Berlin, and has had more than 350,000 audience members in dozens of cities around the world. In 2013, Los Angeles was the first city to host performances of the opera outside Berlin, and it’s featured two more runs since.

Stage director Barrie Kosky was inspired to create this version of The Magic Flute after he attended a performance of a show called Between the Devil and the Deep Blue Sea. It was the inaugural presentation from a British theater company called 1927, which first formed in 2005 in the UK. “From the moment the show started, there was this fascinating mix of live performance with animation, creating its own aesthetic world,” says Kosky in an interview with Ulrich Lenz. “Within minutes, this strange mixture of silent film and music hall had convinced me that these people had to do The Magic Flute with me in Berlin!

Ildebrando D’Arcangelo as Sarastro in LA Opera’s 2019 production of “The Magic Flute”/ Cory Weaver

A World of Dreams and Nightmares

Filmmaker Paul Barritt and director/writer/performer Suzanne Andrade are the co-creators of 1927, named after the year that the first talking pictures hit the silver screen. “We work with a mixture of live performance and animation, which makes it a completely new art form in many ways,” Andrade explains. “Many others have used film in theater, but 1927 integrates film in a very new way. We don’t do a theater piece with added movies. Nor do we make a movie and then combine it with acting elements. Everything goes hand in hand. Our shows evoke the world of dreams and nightmares, with aesthetics that hearken back to the world of silent film.”

While The Magic Flute by Mozart first premiered in 1791, this interpretation takes place in Berlin in the 1920s, a hotspot for European counterculture at the time. Papageno is modeled after Buster Keaton; Monostatos recalls Nosferatu; and Pamina bears a striking resemblance to Louise Brooks. The deft combination of costumes, animations, and unmatched vocal styling combine for a one-of-a-kind production with fairly insane visuals, including references to perennial pop-culture favorites such as comic books and vintage martial-arts movies.

Bogdan Volkov as Tamino in LA Opera’s 2019 production of “The Magic Flute”/ Cory Weaver

“This emphasis on the images makes it possible for every viewer to experience the show in his or her own way: as a magical, living storybook; as a curious, contemporary meditation on silent film as a singing silent film; or as paintings come to life,” Kosky says. “Basically, we have a hundred stage sets in which things happen that normally aren’t possible onstage: flying elephants, flutes trailing notes, bells as showgirls… We can fly up to the stars and then ride an elevator to hell, all within a few minutes.”

In the end, while it’s easy to love this particular version of The Magic Flute, it’s not easy to define it. We know it’s an opera, but it’s so much more than that. So what is it, exactly? Maybe Kosky describes it best: “It’s a silent film by Wolfgang Amadeus Mozart, so to speak!”

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